Grape Polyphenols’ for improving decline in muscle function
1|Capozzi Adriana|Montpellier|PhyMedExp|France|
2|Bisbal Catherine|Montpellier|PhyMedExp|France|
Skeletal muscles account for 40% of our total body weight and are responsible for more than 80% of glucose uptake after insulin stimulation, highlighting their central role in metabolism regulation. Increasing evidence underscores the pivotal role of skeletal muscle in the systemic regulation of age-related diseases [1]. Functional and metabolic alterations in muscles, alongside a decrease in skeletal muscle mass, have been consistently linked to human mortality rates [2,3]. Consequently, impairment of skeletal muscle mass and/or function can precipitate major pathologies such as insulin resistance and type 2 diabetes, as well as weakness and disability, substantially diminishing quality of life and heightening the risk of morbidity and mortality [4,5]. While regular physical exercise is widely acknowledged as fundamental to a healthy lifestyle, maintaining consistent exercise routines can pose challenges for various reasons. Grape polyphenols, a distinguished group of plant bioactive compounds, have emerged as promising candidates with exercise mimetic properties [6]. In our study, conducted using both in vitro models of human muscle cells and in vivo rodent models, we demonstrated that low doses of polyphenolic extracts from grapes can enhance muscle metabolism and increase muscle mass in conditions of obesity. In conclusion, grape polyphenols present a compelling avenue for individuals to enhance their adherence to regular physical activity by promoting muscle adaptation.